PDF versionModule Leader
Lecturers
Prof V Deshpande and Prof N Fleck
Timing and Structure
Lent term. 14 lectures + 2 examples classes. Assessment: 100% exam
Prerequisites
3C7 useful.
Aims
The aims of the course are to:
- deal with the relation between microstructure of and properties such as strength, stiffness and actuation capability of natural materials such as cells and tissues and their properties, including stiffness.
Objectives
As specific objectives, by the end of the course students should be able to:
- understand the relation between micro-structure of soft biological materials and their mechanical properties.
- have a working understanding of the various components within plant and animal cells with a more detailed knowledge of the cytoskeletal components.
- understand the origins of the mechanical forces generated due to the polymerization of cytoskeletal proteins and derive the key equations.
- develop an understanding of muscles as actuators at the tissue, cell and protein length scales.
Content
Overview Lecture (Prof N. A. Fleck 1L)
The microstructure of the cell – animal cells, plant cells and the sub-cell building materials.
Mechanical Properties of Soft Solids (4L) (Prof. N A Fleck)
- The mechanical properties of natural materials – property maps
- Bending versus stretching micro-structures and entropic networks
- The notion of persistence length
- Models of stiffness and strength
- Mechanics of skin: stress v. strain responses, toughness and skin injection
The cytoskeleton (4L) (Prof.V. Deshpande)
- Review of basic thermodynamics and kinetics
- Introduction to cytoskeletal components and basics mechanics of the filaments
- Re-organization of the cytoskeletal filaments: polymerization, force generation and an introduction to motility
Muscle Mechanics (5L) (Prof.V. Deshpande)
- Twitch and tetanus and the Hill model
- Structure of the muscle: fibers, fibrils and contractile proteins
- Sources of energy in the muscle- Lohmann reaction
- Huxley Sliding filament model
- Models of myosin
Further notes
Further details and online resources:-
http://www-g.eng.cam.ac.uk/lifesciences/courses.html
Booklists
Please see the Booklist for Group G Courses for references for this module.
Examination Guidelines
Please refer to Form & conduct of the examinations.
UK-SPEC
This syllabus contributes to the following areas of the UK-SPEC standard:
Toggle display of UK-SPEC areas.
GT1
Develop transferable skills that will be of value in a wide range of situations. These are exemplified by the Qualifications and Curriculum Authority Higher Level Key Skills and include problem solving, communication, and working with others, as well as the effective use of general IT facilities and information retrieval skills. They also include planning self-learning and improving performance, as the foundation for lifelong learning/CPD.
IA1
Apply appropriate quantitative science and engineering tools to the analysis of problems.
IA2
Demonstrate creative and innovative ability in the synthesis of solutions and in formulating designs.
KU1
Demonstrate knowledge and understanding of essential facts, concepts, theories and principles of their engineering discipline, and its underpinning science and mathematics.
KU2
Have an appreciation of the wider multidisciplinary engineering context and its underlying principles.
E1
Ability to use fundamental knowledge to investigate new and emerging technologies.
E2
Ability to extract data pertinent to an unfamiliar problem, and apply its solution using computer based engineering tools when appropriate.
P3
Understanding of contexts in which engineering knowledge can be applied (e.g. operations and management, technology, development, etc).
US1
A comprehensive understanding of the scientific principles of own specialisation and related disciplines.
US3
An understanding of concepts from a range of areas including some outside engineering, and the ability to apply them effectively in engineering projects.
Last modified: 02/10/2018 13:47